Urticarial vasculitis appear as a multisystem disease, that affect on skin surface big, itchy, red lesions, similar like urticaria, except that wheals persist more than 24 h, generally up to 3 to 4 days. Also, in addition to lesions, the disease is characterized with symptoms like fever, arthralgia, elevated sedimentation rate, and histologic findings of a leukocytoclastic vasculitis. The syndrome is often accompanied by various degrees of extracutaneous involvement. May be cutaneous manifestations of SLE.
The mainly cause of the Urticarial vasculitis is breaking of the immune system. Deposition of antigen-antibody complexes in cutaneous blood vessel walls leads to complement activation, resulting in neutrophil chemotaxis; collagenase and elastase released from neutrophils cause vessel wall and cell destruction.
The very first symptomatic condition of the Urticarial vasculitis is an urticarial eruption that is often painful or has a burning sensation. In some cases there may be pruritus (itching). The formed lesions on the surface of skin of variety areas of the body are red patches that may have a white centre and petechiae (small spots of bleeding under the skin) may appear. Lesions usually last for more than 24 hours in a fixed location after which they will slowly resolve spontaneously. Ecchymoses (bruise-like patches) or hyperpigmentation (darkening of the skin) may occur in the healing process. It is not contagious disease.